One of the little mysteries of the 2000 elections was how Al Gore managed to lose his own home state of Tennessee. Of course, most on the right seized on the notion that he never really lived there, but generally, I suspect it's just that his state has been trending more conservative in recent years. Had he not become Vice President in 1993, I wonder if he would have even been re-elected to his Senate seat in his next election.
Stuff like this makes me think, probably not. "Crimes of nature", indeed.